Academy of Finland
Funding decision
Applicant / Contact person Michon, Frederic
Organisation University of Helsinki
Project title Nature of the molecular signals supporting cornea renewal and wound healing
Decision No. 326100
Decision date 22.05.2019
Funding period 01.09.2019 - 31.08.2023
Funding 499 712
WebFOCUS Report
Project description
The cornea, transparent surface of the eye is instrumental to clear vision. Injuries or diseases can lead to a loss of cornea transparency, and ultimately loss of sight. Around 28 million people suffer from uni- or bi-lateral corneal blindness worldwide. The most prominent causes are Dry Eye Syndromes (up to 34% of the elderly), and corneal abrasions (about 1 million cases per year in USA alone). My lab recently demonstrated that after an insult on the eye surface, the lacrimal gland reacts swiftly to modulate the tear composition. The resulting tears can support the cornea wound healing via a cocktail of factors. In case of defected lacrimal gland, the wound healing process is impaired. In the proposed project, my lab will take advantage of the mouse and zebrafish to decipher the lacrimal gland cornea synergy. This strategy will open new avenues to develop therapeutic ways to treat corneal insults, post-surgery recovery, or age-related defects.