In this study we aim to prevent severe epilepsy of infancy, infantile spasms syndrome. We also aim to improve cognitive development of those children, and to develop a predictive marker of cognitive changes.
We recruit 140 children born in Finland, and aged less than one year, who have increased risk of developing that epilepsy due to their previous neurological diagnosis.
We examine repeatedly electroencephalograms during the first year of life. When seeing epileptiform changes in them, patients are randomized to antiepileptic medication vigabatrin (up to one year of age) or to control group with no prophylactic treatment. Patients undergo also frequent eye tracking analyses, pediatric neurological, neuropsychological, and ophthalmological examinations.
We assume that in vigabatrin group the occurrence of infantile spasm syndrome is reduced, and development is better than in controls, and eye tracking analysis can predict abnormalities of their cognitive development.