Academy of Finland
Funding decision
Applicant / Contact person Martikainen, Riikka
Organisation University of Eastern Finland
Project title Mitochondrial cardiomyopathy; molecular mechanisms and clinical variation
Decision No. 324958
Decision date 22.05.2019
Funding period 01.09.2019 - 31.08.2023
Funding 502 579
WebFOCUS Report
Project description
Mitochondrial cardiomyopathies are heart diseases arising from primary defects in energy producing mitochondria. Currently no treatments exist for these diseases and detailed molecular mechanisms underlying disease pathology are unknown. Recent advances in stem cell technology have opened up new ways for using patient material through generation of induced pluripotent stem cells (iPSCs) and differentiation of these to disease relevant cell types. This proposal utilizes iPS-lines generated from mitochondrial cardiomyopathy patients in investigating molecular mechanisms leading to the disease phenotype and in identification of putative drug targets and predictive biomarkers.