Academy of Finland
Funding decision
Applicant / Contact person Korhonen, Rami
Organisation University of Eastern Finland
Project title A novel mechanobiological algorithm to reveal mechanisms in the progression of different phenotypes of osteoarthritis
Decision No. 324529
Decision date 22.05.2019
Funding period 01.09.2019 - 31.08.2023
Funding 543 234
WebFOCUS Report
Project description
Osteoarthritis is a common joint disease affecting over 40 million Europeans. The number of patients with the disease is increasing. There is no cure for the disease, thus, preventing the progression of osteoarthritis would be the most helpful and cost-effective. However, this is currently not possible because the exact etiology of osteoarthritis is not known, and prevention and personalized treatment is possible only if the disease progression can be predicted. In this project, we develop a mechanobiological algorithm that can be used to predict the progression of different subtypes of osteoarthritis and optimize intervention. The algorithm accounts for biochemical and biomechanical degenerative mechanisms, and it is developed with the support of experimental data. This project is done in collaboration with Massachusetts Institute of Technology, University of Calgary, Cleveland Clinic, University of California San Francisco, Kuopio and Helsinki University Hospitals and Mehilšinen.