Academy of Finland
Funding decision
Applicant / Contact person Shulga, Anastasia
Organisation Helsinki University Central Hospital
Project title Long-term paired associative stimulation - reversing paresis and paralysis
Decision No. 324160
Decision date 22.05.2019
Funding period 01.09.2019 - 31.08.2021
Funding 250 000
WebFOCUS Report
Project description
Spinal cord injury (SCI) has a devastating effect on the quality of life, and constitutes an economic burden for society. There is a need for novel safe and effective treatments that could be fast incorporated into medical practice. Paired associative stimulation (PAS) is a technique where noninvasive brain stimulation is synchronized with peripheral nerve electrical stimulation. PAS induces transient plastic changes in human corticospinal tract. We were the first ones to apply PAS to SCI patients as a long-term treatment with successful outcome. We show the clinically relevant and long-term therapeutic effect of PAS in chronic SCI patients. We will confirm the results and further develop the method in a larger population of SCI patients, seek for optimal parameters performing measurements in healthy volunteers, and pilot the expanding of the method to stroke patients. The ultimate goal is to bring our approach from experimental stage into real clinical practice.