Academy of Finland
Funding decision
Applicant / Contact person Sierra Lopez, Alejandra
Organisation University of Eastern Finland
Project title From 3D electron microscopy tissue model to pathology specific multidimensional diffusion MRI
Decision No. 323385
Decision date 22.05.2019
Funding period 01.09.2019 - 31.08.2023
Funding 481 881
WebFOCUS Report
Project description
Rapidly increasing burden of neurological disorders demands an improvement of non-invasive imaging tools for more accurate and early diagnostics, and outcome prediction than currently clinically available. This project will develop more specific non-invasive magnetic resonance imaging (MRI) acquisitions by using the morphological information of the brain tissue obtained by 3D electron microscopy. The outcome will be highly specific imaging methods to particular cellular structures and active pathological processes critical during brain diseases such as neurodegeneration, inflammation, or plasticity. Introducing the real tissue information can have unprecedented repercussion in the early diagnosis of neurodegenerative diseases, mental disorders, stroke, tumors, or brain injury. The generated imaging methods obtained in this project can be implemented in clinical scanners, and have a long-term impact in clinical diagnostics.