Academy of Finland
Funding decision
Applicant / Contact person Ihalin, Riikka
Organisation University of Turku
Project title Molecular mechanisms of the information warfare between host and pathogen
Decision No. 322817
Decision date 22.05.2019
Funding period 01.09.2019 - 31.08.2023
Funding 513 324
WebFOCUS Report
Project description
The ability of bacteria to sequester human signal molecules can be related to informational warfare where the enemy’s information signals are used to obtain competitive advantage. The chemokine interleukin (IL)-8 is crucial for the efficient recruitment of neutrophils in healthy periodontium. Our recent data indicates that a periodontal pathogen can sequester and uptake IL-8. This study clarifies the molecular mechanisms which bacterium uses when it perceives the inflammatory milieu and disturbs the host defense. We characterize the bacterial chemokine uptake machinery and investigate the bacterial response to IL-8 uptake. We investigate also the effect of bacterial cytokine sequestering on host response. The study opens possibilities to search for novel treatments for chronic infections, such as periodontitis. In the era of increasing amount of antimicrobial resistance molecular level information about bacterial virulence mechanisms is needed in battle against pathogenic bacteria.