Academy of Finland
Funding decision
Applicant / Contact person Löytynoja, Ari
Organisation University of Helsinki
Project title Infidelity and partner swapping: template switch mutations through time and space
Decision No. 322681
Decision date 22.05.2019
Funding period 01.09.2019 - 31.08.2023
Funding 495 925
WebFOCUS Report
Project description
The fidelity of DNA replication is central for the short-term survival of the organism while the evolution enabled by the replication errors is crucial for its long-term success. The project studies the properties of local template switch mutations, causing short stretches of dissimilarities between the sequences, across various species and their genomes. A subset of template switch mutations create or correct reverse-complement sequences. The role of these in the evolution of RNA genes is examined.