Academy of Finland
Funding decision
Applicant / Contact person Pitkänen, Esa
Organisation University of Helsinki
Project title Deep probabilistic modeling of somatic mutagenesis
Decision No. 322675
Decision date 07.05.2019
Funding period 01.09.2019 - 31.08.2024
Funding 438 874
WebFOCUS Report
Project description
Somatic mutations cause many types of diseases such as cancers. This project aims to unravel the determinants of how somatic mutations arise by developing state-of-the-art machine learning tools and investigating the genomes of >10,000 human tumors across multiple tumor types. As a result we will deliver models of somatic mutagenesis in cancer of unprecedented detail and accuracy, with models representing over 50,000,000 somatic mutations. These models will reveal genetic and epigenetic factors which influence mutational processes, shedding light on the complex interaction of genetic and environmental causes of mutations. Importantly, we will able to develop diagnostic and prognostic tools, which will be translated to clinical practice at the Helsinki University Hospital Comprehensive Cancer Center. These tools will substantially improve the healthcare and quality of life for cancer patients in Finland and worldwide.