Academy of Finland
Funding decision
 
Applicant / Contact person Meinander, Annika
Organisation Åbo Akademi University
Project title TARGETING UBIQUITIN SIGNALLING IN CHRONIC INFLAMMATION
Decision No. 321850
Decision date 22.05.2019
Funding period 01.09.2019 - 31.08.2023
Funding 499 770
WebFOCUS Report
Project description
Diseases involving chronic inflammation, such as inflammatory bowel disease (IBD) are increasing in Finland and worldwide, especially among young people. Apprehensively, IBD such as ulcerative colitis and Crohn’s disease is a major risk factor for colorectal cancer. Similarly, chronic inflammation in the lung epithelia due to asthma or pulmonary disease is associated with lung cancer. My laboratory studies how a protein modification named ubiquitination regulates inflammation in the cells in the intestine and the airways. As inflammatory signalling is very complex in mammalian cells, we use the fruit fly Drosophila melanogaster as a model organism in our studies. Our research will enhance our understanding of protein regulation in inflammatory cell signalling, and this knowledge may open up possibilities for discovery of new drug targets and diagnostic markers for chronic inflammation.