Academy of Finland
Funding decision
Applicant / Contact person Leppänen, Olli
Organisation Tampere University Hospital
Project title DupuytrEn Treatment EffeCtiveness Trial (DETECT)
Decision No. 321838
Decision date 22.05.2019
Funding period 01.09.2019 - 31.08.2023
Funding 401 055
WebFOCUS Report
Project description
Dupuytren's contracture (DC) is a common benign soft tissue disease of the hand affecting millions of people in northern Europe and Northern America. It causes thickening of palmar fascia (connective tissue of the hand) and results in flexion contracture of fingers. The treatment is division of thickened connective tissue cord in operation, or division with a needle or dissolving it enzymatically (a drug). Currently, we do not know, which treatment yields best outcomes (hand function, satisfaction) with least harms and costs. The aim of the trial is to investigate three treatment strategies in long term to identify the most effective and cost-effective treatment in 5-years follow-up. We are performing a national trial in six hospitals in Finland and will recruit 287 participants. We will measure outcomes and costs at 3-months, 2-years, 5-years and 10-years. Our study will inform patients and society which treatment strategy should be adapted to treat this condition.