Suomen Akatemia
Hakija / Yhteyshenkilö Nieminen, Anni I
Organisaatio Helsingin yliopisto
Tutkimusaihe Syöpäsolujen metabolinen adaptaatio - mekanismeista syövänhoitostrategioihin
Päätös 316323
Päätöspvm 18.06.2018
Rahoituskausi 01.09.2018 - 31.08.2021
Rahoitus (€) 270 457
WebFOCUS Report
Hankkeen julkinen kuvaus
Metabolism of cancer cells has a significant role in tumour growth. Recently this topic has received a lot attention and is one of the focus areas of cancer drug development. Here we suggest an approach to better understand regulatory networks involved in dynamic control of cancer cell metabolism. By exposing hepatocellular carcinoma cells to starvation on a critical nutrient we aim to unveil cancer cell-specific capacities to activate alternative pathways required for survival. These adaptive responses will be then systematically targeted to identify the most effective combinations for therapeutic use. Collectively, this project introduces a novel concept to target cancer metabolism and will provide new information about the dynamic control of cancer cell metabolism, which may eventually lead to more specific and effective treatments.