Finlands Akademi
Sökande / Kontakt person Lahtela-Kakkonen, Maija
Organisation Östra Finlands universitet
Projektets titel Dual-targeting of BET and sirtuin proteins in cancer
Beslutnr 315824
Beslutsdatum 18.06.2018
Finansierings period 01.09.2018 - 31.08.2022
Finansiering 476 598
WebFOCUS Report
Beskrivning av projektet
Chemotherapy is used to treat many types of cancer. Chemotherapy has high response rates for certain tumors but it does not work well for solid tumors. Regulation of the acetylation status of chromatin core proteins, histones, is a central mechanism in epigenetic control. Disruption in the acetylation signalling plays a part in several diseases including various cancers. Regulation is controlled by mammalian Bromo and Extra Terminal (BET) family of bromodomain proteins and histone deacetylases, in which sirtuins belongs. BET family has been linked to the development of a number of extremely aggressive tumours. Sirtuins are also involved in several cancers. This project will for the first time offer a functional connection between BET proteins and sirtuins in cancer cells. In addition the dual-targeting of BETs and sirtuins will examined. It can be a promising strategy in cancer treatment and can give advantages over mono-targeting.