Miniaturization of sample volumes and corresponding analytical devices has been one of the major goals in bioanalytics. Existing solutions are based on either unnecessarily complicated devices or application-specific microfluidic chips. In this project, we propose to use transverse vibrations of a disposable plate to move, mix, merge and split drops on the plate. The vibrations are controlled in closed-loop. Variety of biochemical assays can be done on the device simply by reprogramming the controller.
The project starts by developing methods to manipulate drops reliably and controllably on the plate. The project will then proceed to demonstrate homogeneous enzyme assays and heterogenous immunoassays on the device. Colorimetric measurements and biosensors will be integrated into the device.
This project contributes to lab-on-chips and point-of-care diagnostics.