Academy of Finland
Funding decision
Name Narkilahti, Susanna
Organisation University of Tampere
Project title Modular platform for epilepsy modeling in vitro (MEMO)
Decision No. 311017
Decision date 20.06.2017
Funding,period 01.09.2017 - 31.08.2021
Funding 400 000
WebFOCUS Report
Project description
Our main aim is to create an in vitro disease model for epilepsy that includes “epileptic” networks cultured under stabile conditions in a modular platform. Sensors and electrode arrays are integrated into the platform so that epileptic phenomena can be detected at a functional level. Cell guiding structures enable a more in vivo like position of cells mimicking better the epilepsy circuits in the brain. Integrated microfluidistics give additional control for medium flow and when correctly designed allow targeted drug testing in the system. This model can be used as one entity platform to monitor epilepsy in a dish. It will be useable tool for the in vitro research of disease mechanisms, drug development and screening and testing of neurotoxic compounds and to develop diagnostic tools to personalized medicine.