The aim of the research project is to develop novel, highly efficient methods to use carbon dioxide (CO2) as an environmentally friendly building block for synthesis of highly valuable pharmaceuticals, chemicals and materials. In this project two different activation pathways are in use, one based on interesting interaction of CO2 and amines (Lewis base) and the other approach based on copper complexes (Lewis acid) and their reactivity with CO2.
The first pathway will be utilized in synthesis of carbamates in general, but especially N-aryl-oxazolidinones (NAOs) which are five-membered cyclic molecules. They differ amongst the rest of urethane-containing pharmaceuticals as a result of their antibiotics activity against a broad spectrum of gram-positive bacterial strains that are resistant to other powerful antibiotics.
In the second pathway the emphasis is on the development of efficient and sustainable catalysis for CO2 based carboxylation of alkyls and aryls.