Academy of Finland
Funding decision
Applicant / Contact person Schleutker, Johanna
Organisation University of Turku
Project title Inherited gene mutations in aggressive prostate cancer
Decision No. 310105
Decision date 28.04.2017
Funding period 01.09.2017 - 31.08.2021
Funding 446 838
WebFOCUS Report
Project description
Prostate cancer (PrCa) is a major challenge for health care worldwide. It is one of the most commonly diagnosed cancers: it affects one in seven men and one in 39 will die of PrCa. PrCa has a wide spectrum of clinical behavior that ranges from decades of indolence to rapid metastatic progression and lethality. PrCa is also among the most heritable of human cancers with 57% of the inter-individual variation in risk attributed to genetic factors. Genome wide association studies (GWAS) have confirmed already over 100 susceptibility loci in the human genome that together account for approximately 33% of the excess familial PrCa risk. The biggest treatment challenge is determination of aggressive PrCa already in early phases of the disease. This research project - based on exiting previous results - aims to develop a solution, a germline genetic test that consists of a novel combination of genetic biomarkers that detects the variants from blood-extracted DNA and predicts disease outcome.