Academy of Finland
Funding decision
 
Name Lohi, Hannes
Organisation University of Helsinki
Project title An omics approach to identify environmental, metabolic and genomic determinants of canine neurobehavioral traits as natural models of human anxiety
Decision No. 308887
Decision date 28.04.2017
Funding,period 01.09.2017 - 31.08.2021
Funding 448 849
WebFOCUS Report
Project description
Anxiety disorders make up the lionís share of neuropsychiatric disease burden with worldwide population incidences of >15%. Anxiety disorders are heritable, but clinically and genetically complex and remain poorly characterized at molecular level. This project uses an omics approach to identify environmental, metabolic and genomic determinants of canine anxiety as models to human anxiety. Dogs manifest naturally occurring heritable behavior disorders homologous to human conditions. We will utilize our behavioral survey to collect information from 50k dogs in seven traits (fear, noise phobia, aggression, compulsion, separation anxiety, ADHD, phobias) categorized to low, medium and high anxiety groups. We will employ quantitative NMR-based metabolomics (>200 markers) to profile 7000 dogs in the extreme groups while genetic analyses will focus on the predisposition a selected trait. Our unique approach may remedy the current lack of a natural model of human anxiety.