Academy of Finland
Funding decision
Applicant / Contact person Karlsson, Linnea
Organisation University of Turku
Project title Early life stress, gut microbiome, and child brain development - the FinnBrain Birth Cohort Study
Decision No. 308176
Decision date 28.04.2017
Funding period 01.09.2017 - 31.08.2021
Funding 448 849
WebFOCUS Report
Project description
Prenatal and early life psychological and physiological stress participate in porgramming of the developing brain. The underlying mechanisms remain unknown. The gut-brain axis has been suggested to be a key player but human data is scarce. This project is part of a larger FinnBrain Birth Cohort Study with 4018 families. In this subproject, ca. 500 children exposed vs. non-esposed to early stress are studied prospectively. Stool samples have been collected at 2.5, 6, 14, and 30 months. Child neuropsychological assessments are performed at 8 and 30 months. Stress is measured by questionnaires and hair cortisol and data on physiological stressors is acquired from registries. Funding is applied for completing analyses and preparing manuscripts. We investigate associations between early stress, gut microbiota and child development. Corresponding human data does not exist. Unique data will be produced with possible applications to prevent and treat diseases with origins early in life.