Academy of Finland
Funding decision
Applicant / Contact person Hiltunen, Mikko
Organisation University of Eastern Finland
Project title Deciphering the novel Alzheimer’s disease-associated targets in synaptic dysfunction
Decision No. 307866
Decision date 28.04.2017
Funding period 01.09.2017 - 31.08.2021
Funding 423 832
WebFOCUS Report
Project description
The current proposal utilizes molecular and cell biological as well as translational medicine approaches to investigate newly identified Alzheimer’s disease (AD)-associated targets in the early stages of disease pathophysiology. The ultimate goal is to establish the mechanistic involvement of the identified AD-associated targets in early pathogenic processes intimately linked to AD, particularly synaptic dysfunction. The project uses different cell-based and animal models that allow detailed elucidation of biological mechanisms of the AD-associated targets in the early stages of AD pathogenesis. Special focus is set on the effects of AD-associated targets on the structural plasticity of dendritic spines, the expression and organization of synaptic targets relevant for AD, pathways known to regulate neuronal survival, and mitochondrial function. It is expected that specific new molecular targets and biomarker candidates in AD will be identified.