Finlands Akademi
Namn Kauppi, Liisa H
Organisation HY
Projektets titel From genomic rearrangements to more efficient treatment in ovarian cancer
Beslutnr 306026
Beslutsdatum 30.09.2016
Finansieringsperiod 01.10.2016 - 30.09.2018
Finansiering 299 142
WebFOCUS Report
Beskrivning av projektet
Ovarian cancer is the most deadly gynaecological cancer. Ovarian cancer genomes are highly unstable, and this instability is one mechanism by which tumors can evade killing by chemotherapy. However, little is known about the functional consequences of individual chromosomal aberrations in this lethal disease. Using our recently developed a PCR-based workflow that enables the detection of DNA rearrangement activity, we have identified genomic regions and signalling pathways that experience recurrent disruptions in ovarian cancer patients. Currently we are investigating whether these alterations confer any growth advantage to ovarian tumors.