Finlands Akademi
Namn Nykter, Matti
Organisation TAY
Projektets titel Prediction of pathway activities from cell free DNA in prostate cancer
Beslutnr 305597
Beslutsdatum 30.09.2016
Finansieringsperiod 01.10.2016 - 30.09.2018
Finansiering 300 000
WebFOCUS Report
Beskrivning av projektet
Liquid biopsy technologies are emerging as non-invasive method for studying cancer treatment responses and also for diagnostics. Cell free DNA especially provides straightforward means to study cancer associated genomic changes from a simple blood sample. We have shown that cell free tumor DNA from men with metastatic prostate cancer contains same driver mutations that are present in match tissue biopsies. We have also improved computational methods to detect somatic alterations, such as copy number changes from cell free DNA samples with low tumor DNA fraction. These methods have been utilized in our recent publications.