Finlands Akademi
Namn Tammela, Päivi
Organisation HY
Projektets titel New antimicrobials against Gram-positive bacteria
Beslutnr 304697
Beslutsdatum 30.09.2016
Finansieringsperiod 01.10.2016 - 30.09.2018
Finansiering 298 874
WebFOCUS Report
Beskrivning av projektet
This project focused on screening of novel compounds based on a natural product scaffold for potential activity against a panel of Gram-positive bacterial strains. To our knowledge this scaffold has not been previously used for developing novel antimicrobials. Our aim was to fully explore the antibacterial potential of these compounds by carrying out, for example, extensive biological profiling and characterisation. Method development was also an important component of this project, in order to proceed with an in-depth characterization of identified potential antimicrobials. We have set up and optimized several methods for further characterization of antibacterial compounds. For example, assays for studying effects on bacterial biofilms and on extracellular polymeric substance components in biofilms have been carried out with the most promising compounds. Assays conditions for screening anti-biofilm agents has also been defined for Gram-positive clinical reference strains.