Finlands Akademi
Namn Sundberg, Lotta-Riina
Organisation JY
Projektets titel Possibilities of biological disease management in aquaculture
Beslutnr 304615
Beslutsdatum 30.09.2016
Finansieringsperiod 01.10.2016 - 30.09.2018
Finansiering 297 316
WebFOCUS Report
Beskrivning av projektet
Aquaculture production is a steadily growing food production industry, but hampered by a variety of diseases. This project focused to study the eradication of the fish pathogen Flavobacterium columnare from the fish farming environment using lytic enzymes derived from bacteriophages, the viruses that infect only bacteria. The lytic enzymes naturally hydrolyse bacterial cell wall during the phage infection cycle, and they have been demonstrated as efficient anti-infectives against several human pathogens. We used whole genome sequences of novel bacteriophages to identify potential genes that encode lytic enzymes. Candidate lytic enzymes were produced in E. coli. The efficiency of the produced lytic enzymes was tested against flavobacterial cultures.