Academy of Finland
Funding decision
Name Surakka, Ida L
Organisation HY
Project title Revealing genetic architecture of dyslipidemias and lipid traits utilizing next generation sequencing data
Decision No. 298149
Decision date 20.06.2016
Funding period 01.09.2016 - 31.07.2017
Funding 99 182
WebFOCUS Report
Project description
The aim of this project has been to study the genetic determinants affecting cardiovascular risk-factors utilizing large Finnish datasets with registry data and to improve statistical methodology used in the research of complex diseases. Specifically, during the project we showed how the imputation accuracy in Finnish population samples can be increased using a whole-genome sequence based reference panel. This allows the future population-studies to genotype more samples with less expenses as they can be imputed into sequence width with high accuracy. Additionally, we used the whole-genome sequence dataset in a collaborative project studying the effects of LPA polymorphisms to cardiovascular diseases and comparing the effects between samples with different ancestries.