Academy of Finland
Funding decision
Name Kauppinen, Anu
Organisation UEF
Project title Fighting against age-related macular degeneration by inhibiting inflammasomes
Decision No. 297267
Decision date 25.05.2016
Funding period 01.09.2016 - 31.08.2021
Funding 434 485
WebFOCUS Report
Project description
Age-related macular degeneration (AMD) is the leading cause of severe vision loss among the elderly in developed countries. Difficulties e.g. to read and live independently restrict the physical, mental, and social life of patients and concern also their families. Increased life expectancies further highlight the economic and national health burden caused by AMD. Degeneration of retinal pigment epithelium (RPE) cells is the primary event resulting in death of photoreceptors, which destroys the central vision. The absence of proper therapy options is largely due to lack of full understanding on the mechanisms of AMD. This study combines the revealing of disease mechanisms and the development of new treatment possibilities with special emphasis on Inflammasomes that are intracellular protein complexes promoting inflammation.