Academy of Finland
Funding decision
Name Mattila, Pieta
Organisation TY
Project title Cytoskeletal Control of B Cell Activation: From Receptor Signalling to the Immune Response
Decision No. 296684
Decision date 25.05.2016
Funding period 01.09.2016 - 31.08.2021
Funding 434 485
WebFOCUS Report
Project description
The adaptive immune system, composed of B and T lymphocytes, plays a critical role in the fight against infections and malignancies. This requires a careful balance between efficient recognition of hostile pathogens while preserving self-tissues untouched. Cellular changes interfering with this balance can lead to several life-threatening conditions, such as immune deficiencies, autoimmunity disorders, and cancer. We investigate the role of the cellular cytoskeleton in regulating the threshold for B cell activation during the immune response using the most modern cell biological and microscopic techniques. We gain fundamental new information on the molecular regulation of B cell activation leading to better understanding of the immune system and immune disorders, as well as the control of receptor signalling in general.