Academy of Finland
Funding decision
 
Name Toddie-Moore, Daniel John
Organisation HY
Project title The molecular mechanisms coupling developmental signalling and epithelial morphogenesis
Decision No. 295013
Decision date 24.05.2016
Funding period 01.09.2016 - 31.08.2019
Funding 258 064
WebFOCUS Report
Project description
Developmental signalling pathways direct changes in tissue morphology and their disruption can cause human diseases. The changes in tissue shape and structure caused by developmental signalling also alter the environment in which signalling pathways act. How continued signalling is coupled with the changes that they cause is an understudied but important part of understanding development. I aim to identify new molecular mechanisms which couple signalling and tissue formation using BMP signalling in the fruit fly wing veins as a model. I have compiled a list of candidate genes that may play a role in this process from those that are targets of signalling and that are required for wing vein formation. The candidate genes that will be investigated also have human homologues that have been implicated in disease. The molecular mechanisms uncovered will therefore be relevant not only for investigating a fundamental developmental concept but also for understanding how these diseases manifest.