Academy of Finland
Funding decision
Name Pihlajamaa, Päivi
Organisation HY
Project title Identification of MYC target genes and delineation of their role in oncogenic functions
Decision No. 288836
Decision date 10.06.2015
Funding period 01.09.2015 - 31.08.2018
Funding 280 000
WebFOCUS Report
Project description
Oncogenes promote growth and proliferation of cancer cells. MYC is one of the most commonly activated oncogenes in many types of cancers, such as leukemia and colorectal cancer, and better understanding of MYC function is important for development of new diagnostic and therapeutic tools. MYC is a transcription factor that affects cellular functions by regulating the expression of its target genes by binding to their regulatory regions. This project aims at delineating the MYC target genes and their regulatory regions that are required for transformation of normal cells to cancer cells. Modern genome-editing methods will be used to delete MYC-binding sites and to activate expression of putative MYC target genes in cultured cells. Transformed cells and the identified target genes will be further characterized using molecular and cell biology methods. The project will be carried out in the research group of Professor Jussi Taipale at the Research Programs Unit, University of Helsinki.