Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of insulin-producing ß-cells in the pancreas. During the last decades the incidence of T1D has been increasing worldwide, and it is record high in Finland.
Both genetic and environmental factors have an important role in the development of T1D. Although the environmental triggers associated with T1D are still unknown, several studies have suggested a connection between enterovirus (EV) infections and T1D.
The aim of this study is to utilize proteomics to characterize EV induced immune responses in different cell types relevant for T1D and to correlate them with plasma proteomics data from EV positive children at risk for developing T1D. Thereby our aim is to create a comprehensive map of the potential associations between EV infections and T1D.
The novel information provided in this study could potentially be used in the prediction and prevention of T1D in the future.