Academy of Finland
Funding decision
Name Tukiainen, Taru
Organisation HY
Project title The X chromosome component of human complex traits and sexual dimorphism
Decision No. 285725
Decision date 10.06.2015
Funding period 01.09.2015 - 31.08.2018
Funding 279 255
WebFOCUS Report
Project description
The X chromosome, unlike its counterpart Y, encodes for a diverse set of genes and is believed to play roles much beyond reproduction. The X chromosome component of human complex traits is, however, poorly characterized, as the sex chromosomes are only rarely analyzed in genetic association studies. Further, the unique genomic characteristics of the X chromosome result in the chromosome and its genetic variation to have different impacts to trait variability, e.g., disease risk, in men and women. This work aims at building a comprehensive understanding on how the X chromosome contributes to the etiology of common autoimmune and neuropsychiatric diseases, and elaborating the potential X-chromosomal origins of the often-pronounced sex differences in these conditions. To this end, large genomics data sets are utilizing to have various angles to the X chromosome: Complementing the disease associations, the sequence variation and the transcriptome of the X will be characterized in detail.