Academy of Finland
Funding decision
Name Kansanen, Emilia
Organisation UEF
Project title Reactive electrophiles as potential therapeutics role of endogenous stress signaling pathways
Decision No. 285468
Decision date 10.06.2015
Funding period 01.09.2015 - 31.08.2017
Funding 185 646
WebFOCUS Report
Project description
Biological systems have developed mechanisms to adapt to both endogenous and exogenous oxidative and electrophilic stress in order to maintain homeostasis. These mechanisms include activation of cell signaling pathways that can detoxify reactive molecules, restore protein homeostasis and inhibit inflammation. Activation of these protective pathways can be utilized in treatment of diseases where oxidative stress and inflammation play a role, such as myocardial ischemia reperfusion injury. The effects of electrophilic drug candidate, nitro-oleic acid was studied and the results suggest that nitro-oleic acid may alleviate the vasoconstrictive effects via the endothelin system. The pleiotropic nature of electrophilic molecules is important to bear in mind in drug development, as each species is likely to have a unique ability to activate different signaling pathways and cause toxicity.