Academy of Finland
Funding decision
Name Lohi, Hannes
Organisation HY
Project title Discovering genetic risk variants for neuropsychiatric disorders and their consequences using dogs, humans and mice
Decision No. 281334
Decision date 09.12.2013
Funding period 01.01.2014 - 31.12.2016
Funding 350 000
WebFOCUS Report
Project description
Children with psychiatric disorders such as obsessive-compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD) suffer from highly disabling symptoms that interfere with their ability to function in day-to-day life. Despite our progress in learning about these conditions, we still do not really understand what genes are involved in ADHD and OCD and how variation in these genes can lead to dysfunction in brain circuits. Our group, the Comparative Behavioural Genomics Consortium (CBGC) has taken a highly innovative approach of studying the neuropsychiatric traits across humans, dogs and mice to gain novel insights about how genetic variants lead to childhood psychiatric disorders and ultimately to identify new avenues for early identification and treatment of these devastating conditions. We discovered new risk loci and genes in dogs and human and continue to model them in mice to understand the affected brain circuits.