Schizophrenia is one of the most severe mental illnesses with an often unfavourable prognosis. We do not yet know the longitudinal course of schizophrenia in real world. This study utilises two valuable, unselected, general population-based samples: The Northern Finland 1986 Birth Cohort 1966 and 1986. The aim of this project is to explore the longitudinal
course and prognosis of schizophrenia from three perspectives: 1. Longitudinal course of illness in schizophrenia, 2. Clinical and neurobiological predictors of course of illness in schizophrenia, 3. Time trends and period effects in course of psychosis. By examining the course of illness in schizophrenia and the factors affecting it (especially in long-term), we may be better able to
enhance the treatments we offer to our patients.