Academy of Finland
Funding decision
Name Vesala, Laura
Organisation TAY
Project title Signalling events in cell-mediated innate immunity in Drosophila: the role of forkhead transcription factors
Decision No. 276360
Decision date 10.04.2014
Funding period 01.09.2014 - 31.08.2017
Funding 253 645
WebFOCUS Report
Project description
An effective immune system is vital for an organism to survive in an environment full of different harmful organisms, pathogens. The vertebrate immune system consists of adaptive (acquired) and innate immunity. Invertebrates have only the innate response to rely on and still they are extremely successful organisms. In Drosophila, as in other animals, the innate immunity includes humoral and cellular parts. The humoral part is quite well understood, but less is known about the cellular response. In Drosophila, there are three different types of blood cells, called the hemocytes. These cells mediate the cellular immune response against, for example, parasitic wasps. The aim of the proposed project is to study the components of the signalling cascades needed to transmit the signal from encountering a pathogen to launching the cellular immune response. A special attention will be on the regulation and target genes of various Fox transcription factors in immune response.