Academy of Finland
Funding decision
Name Ruskamo, Salla
Organisation OY
Project title Structure and organization of myelin-specific integral membrane proteins
Decision No. 275225
Decision date 10.04.2014
Funding period 01.09.2014 - 31.05.2018
Funding 250 373
WebFOCUS Report
Project description
Myelin insulates axons in the central and peripheral nervous system of all vertebrates enabling the fast transduction of nerve impulses. This project focuses on three myelin-specific integral membrane proteins; proteolipid protein, DM20 and peripheral myelin protein of 22 kDa which all are essential for the compaction and stability of myelin. The aim is to study the 3D structures and interactions of these proteins as well as their organization on multilayered membrane systems. The results will clarify their role in myelin formation and maintenance, as well as the molecular mechanisms behind the demyelinating diseases.