Finlands Akademi
Namn Kronholm, Ilkka
Organisation JY
Projektets titel Epigenetic basis of phenotypic plasticity and its role in evolution
Beslutnr 274769
Beslutsdatum 10.04.2014
Finansieringsperiod 01.09.2014 - 31.08.2017
Finansiering 248 785
WebFOCUS Report
Beskrivning av projektet
This project investigated the role of epigenetic changes (DNA methylation and histone modifications) in how organisms adapt to their environment in the short and in the long-term. Before it was already known that in certain cases epigenetic changes can be inherited, but their role in evolution was not well understood. We showed using a mathematical model that epigenetic changes can affect the dynamics of evolutionary adaptation. We also obtained experimental support for this idea from evolution experiments. Furthermore, we investigated the role of epigenetic mechanisms in short term physiological adaptation to environmental changes. Using the filamentous fungus Neurospora as a model species, we showed that epigenetic mechanisms are important in short term acclimation. Different histone modifications have different effects in different environments. These results help us to understand how organisms adapt to changing environmental conditions in a rapidly changing world.