In this project a controlled and targeted drug delivery method was designed. The method is based on liposomes which contain components converting light to heat. Upon shining light on liposomes, they are heated up, causing fluidization of the lipid wall and a consequent drug release from liposomes.
Studied issues were: 1) heat absorption into liposomes; 2) heat dissipation into lipid matrix; 3) testing the method with cell cultures and bioassays. Work contained both experiments and molecular dynamics (MD)modeling.
Work was done in collaboration between Aalto University and University if Helsinki (UH). In Aalto, items 1 and 2 above are studied as well as MD modeling and at UH item 3.
Dozens of liposome formulations were tested and the conversion from light to heat worked, releasing drugs. Liposomes were internalized in retina pigment epithelium cell cultures showing no toxic side effects. The method provides a new means to treat diseases
in the bottom of an eye.